A recent study suggests that people who discontinue new weight-loss injections like Wegovy and Mounjaro can put back on lost weight far faster than those who end conventional diet and exercise programs.
Research printed in a leading medical journal shows that while overweight people frequently drop a large proportion of their total mass while undergoing treatment, the weight comes back at an estimated rate of 0.8 kg per month once they quit.
"Users purchasing these drugs must be informed of the potential of fast rebound weight gain when the medication concludes," stated expert Dr. Susan Jebb.
Such speed of regain means a return to pre-treatment mass in about one and a half years.
Weighing Therapies
The research, which reviewed 37 of trials involving thousands of patients, contrasted the outcomes of GLP-1 agonists with older methods.
Scientists emphasize that individuals who lose weight through lifestyle changes alone usually have a less rapid weight regain—around 100 grams monthly—after stopping.
The Reason for the Fast Rebound
Experts believe the mechanism of the injections explains the amplified regain.
GLP-1 drugs imitate a natural hormone called GLP-1, which moderates hunger.
"Sustained high doses of the hormone levels several times higher than the body's typical production may cause the system to produce less of its own natural GLP-1, and could lessen sensitivity to its effects," noted Dr. Adam Collins, a dietetics expert.
"Discontinuation of this hormone supplement leads to hunger is no longer kept in check, making overeating far more likely."
A Chronic Condition?
Health authorities advise the jabs for people with weight-linked health risks, alongside recommended diet and exercise modifications.
Many experts say that, considering the likelihood of relapse, the therapy should be considered life-long.
This view is reinforced by drug manufacturers, who say that the results "highlight the persistent nature of obesity," comparing it to managing conditions like diabetes.
User Accounts
Individuals who have stopped the medication report a intense return of appetite.
"I experienced a switch flipping and I was suddenly starving," recalled one woman.
The struggle is worsened if users have not established permanent lifestyle or habit modifications during treatment.
Significant Interest
Survey data indicate that millions of people in the UK have used weight-loss jabs in the last 12 months, with desire continuing to grow.
- Use is greater among females compared to males.
- The middle-aged age group shows the highest level of interest.
- Many obtain the medications through private healthcare rather than public health services.
In conclusion, clinicians stress that while GLP-1 drugs are powerful agents for shedding pounds, they are not a permanent fix and lasting health benefits relies on combined lifestyle changes.
